Joao Soares, Ph.D.
Laboratory Website
The Engineered Tissue Multiscale Mechanics & Modeling (ETM3) Laboratory aims to develop highly-integrative experimental-computational approaches for cardiovascular tissue engineering, in particular, for small-caliber engineered tissue vascular grafts for coronary artery bypass surgery and epicardial restraint patches for myocardium support after infarction.
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Engineered Tissue Multiscale Mechanics & Modeling (ETM3) Research Modus Operandi. Simulation, experimentation, and theoretical development in tissue engineering must supplement each other – our research focus on the development of theoretical models/frameworks to improve fundamental and mechanistic understanding of engineered tissue growth & development, to describe/predict empirically observed phenomena, and to employ them as rational tools for exploration of incubation and implantation protocols. Specifically, our research program relies in a three-pronged approach involving close-loop experiments-theory-simulation: (1) we develop theoretical frameworks describing biomedical phenomena, (2) we deploy them into in silico tools for biomedical simulation; and (3) we carefully design and conduct in vitro and in vivo experiments for validation and refinement.